The study of molecules of the immune system by applying informatics techniques.  This study aims the efficient and effective prediction of immunogenicity. This may be done at the level of epitopes, sub-unit vaccines, or weakened or inactive pathogens.

The ability of a pathogen or a part or molecule of a pathogen to induce a specific immune response when first exposed to surveillance by the immune system is known as Immunogenicity. The capacity for recognition by the adaptive immune response molecular machinery in a recall response is known as Antigenicity.